Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. The making of chloroquine Plaquenil and liver toxicity Hydroxychloroquine ayuda a bajar de peso Chloroquine CQ, traditionally used as an antimalarial medication, has emerged as a prospective adjunct in tumor therapy. CQ has been found to strongly potentiate the inhibitory effect of radiation on cancer cell proliferation, presumably via negative regulation of DNA repair processes. Introduction. Chloroquine is an antimalarial drug that has been used in humans for many years 1. In recent years, Chloroquine has been shown to inhibit autophagy and induce apoptosis in malignant cells and thus has been tested in various experimental model systems 2 and in human clinical trials 3, 4. The combination of chloroquine with zinc enhanced chloroquine’s cytotoxicity and induced apoptosis in A2780 cells. Thus chloroquine is a zinc ionophore, a property that may contribute to chloroquine’s anticancer activity. Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine apoptosis Chloroquine Is a Zinc Ionophore - PubMed Central PMC, Chloroquine Is a Zinc Ionophore - PLOS Chloroquine and primaquine dose Chloroquine-induced activation of apoptosis led us to study its effects on expression of the pro-apoptotic protein PUMA. SK-MEL23 and VMM39 melanoma cells were treated with etoposide as an activator of p53-mediated PUMA induction Nakano and Vousden, 2001 ; Yu et al. 2001 or with different concentrations of chloroquine 25 and 50μM. Chloroquine Promotes Apoptosis in Melanoma Cells by.. Chloroquine & Hydroxychloroquine supporting chemo.. Chloroquine Indications, Side Effects, Warnings -. Materials and methods. Ten-day-old HI rat pups were sacrificed for brain pathological examination and immunohistochemical analysis. The induction of autophagy, apoptosis and MD were also determined in the neurons under hypoxia, with or without autophagy inhibitor, chloroquine CQ treatment. Targeting apoptosis, angiogenesis and oxidative stress has also been described as efficient tools in augmenting sunitinib anticancer activity. Chloroquine diphosphate, a well-known anti-malarial drug, has been under focus due to its potential cytotoxicity in human cancer cells. Blocking autophagy using chloroquine magnified Luteolin-induced apoptosis in the metastatic SCC cells. Conclusion Together, these results suggest that Luteolin has the capacity to induce selectively apoptotic cell death both in primary cutaneous SCC cells and in metastatic SCC cells in combination with chloroquine, an inhibitor of.