Plaquenil for sarcoidosis

Discussion in 'Generic Chloroquine' started by vbios, 18-Mar-2020.

  1. movik User

    Plaquenil for sarcoidosis

    Earlier recommendations suggested an initial dose of 1 mg/kg/d of prednisone; however, more recent expert opinions endorse a lower dose (eg, 40 mg/d), which is tapered to every-other-day long-term therapy over several weeks. In one study, treatment of acute exacerbations of pulmonary sarcoidosis with steroid doses as low as 20 mg of prednisone for a median of 21 days improved spirometry back to baseline and improved clinical symptoms.

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    Hydroxychloroquine brand name, Plaquenil and chloroquine brand name, Aralen are medications that are typically used to treat malaria, a mosquito-borne infectious disease. They can also be used to manage certain symptoms of sarcoidosis. Amongthese drugs, both chloroquine and hydroxychloroquine have also been beneficialin patients affected with cutaneous or extracutaneous sarcoidosis. 4,5,9 However, responses to antimalarialtherapy may be incomplete, and resistance is not a rare finding, thus warrantingthe need for alternative nonsteroidal therapies. However, because sarcoidosis is often a chronic condition, long-term treatment with corticosteroids may cause significant toxicity. Therefore, corticosteroid sparing agents are often indicated in patients requiring chronic therapy. This review outlines the indications for treatment, corticosteroid treatment.

    However, data suggest early treatment of stage II sarcoidosis with oral prednisolone for 3 months followed by inhaled budesonide for 15 months improves 5-year pulmonary function and reduces the need for future steroid treatment. Some data suggest that corticosteroid use may be associated with increased relapse rates.

    Plaquenil for sarcoidosis

    How effective is Plaquenil for Sarcoidosis by duration., The Use of Tetracyclines for the Treatment of Sarcoidosis.

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  6. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others.

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    In people treated with Plaquenil as a disease-modifying antirheumatic drug, the drug was found to have other beneficial effects. Plaquenil was found to improve lipid profiles, control glucose and reduce the risk of diabetes mellitus, and lower the risk of thrombosis in certain people who are at greater risk.   Nov 25, 2019 Usual Adult Dose for Rheumatoid Arthritis. -Initial dose 400 to 600 mg 310 to 465 mg base orally once a day to optimum response usually 4 to 12 weeks -Maintenance dose 200 to 400 mg 155 to 310 mg base orally once a day Dose adjustment The dose may need to be reduced temporarily if adverse side effects occur; Hydroxychloroquine. As a treatment for sarcoidosis, the antimalarial drug hydroxychloroquine Plaquenil® is most likely to be effective in patients with dermatologic involve-ment, joint manifestations and hypercalcemia. Due to poten-tial macular toxicity, it is recommended that patients on hydroxychloroquine have an eye examination every 6-12 months.

  7. vortexcamx Well-Known Member

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  8. joost Guest

    What are the side effects of using hydroxychloroquine. Oct 13, 2019 Hydroxychloroquine Plaquenil and sulfasalazine Azulfidine are used for mild rheumatoid arthritis. They are not as powerful as other DMARDs, but they usually cause fewer side effects. In rare cases, Plaquenil can adversely affect the eyes, and people taking this medicine should be seen by an ophthalmologist at least once a year.

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