Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine q fever Doxycycline chloroquine Chloroquine diphosphate and penicillin Does plaquenil help with sex drive Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Nausea and diarrhea This can often can be combatted by taking Plaquenil with food or milk. If you experience stomach upset while taking generic hydroxychloroquine, ask your doctor about trying name-brand Plaquenil instead. Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil for diarrhea Hydroxychloroquine Oral Route Side Effects - Mayo Clinic, Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Plaquenil liquidBest alternative to plaquenilMucinex and hydroxychloroquinePlaquenil side effects antimalarial Ginny, I had some very minor diarrhea, nausea, cramping for about a week when I started Plaquenil. Everyone is different, but for me, taking the med about 15 min. after eating, rather than before or with a meal, makes things much easier on my stomach, even for just Advil. I do think you should let your rheumy know. Plaquenil = explosive diarrhea -. Taking Plaquenil for Rheumatoid Arthritis. Plaquenil Oral Uses, Side Effects, Interactions.. Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. I’ve been on plaquenil for almost 3 years and I still have diarrhea and to a lesser extent heartburn and nausea sometimes. The first year or two I was on plaquenil I didn’t have a normal bowel movement for as long as I could remember and was constantly nauseous and could barely eat. I've been on Plaquenil for almost 2 wks now and I'm also taking Prednisone, could one of these be causing my extreme stomach cramps? 2 nights ago, I had a cheeseburger and mac and cheese and I thought I was going to die about 1 in the morning. I ended up throwing up once and then I had diarrhea for a bit and then it passed once my system cleared.