It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Plaquenil and macular degeneration Saltwater fish chloroquine compatibility Can hydroxychloroquine affect synthroid absorption Hydroxychloroquine HCQ enhances the anti-cancer activity of the histone deacetylase inhibitor, vorinostat VOR, in pre-clinical models and early phase clinical studies of metastatic colorectal cancer mCRC. Mechanisms could include autophagy inhibition, accumulation of ubiquitinated proteins, and subsequent tumor cell apoptosis. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Drugs that inhibit CYP3A4 enzymes may increase plasma levels of hydroxychloroquine. Proton pump inhibitors may antagonize the immunomodulating effects of hydroxychloroquine. 7. Additional known interactions between hydroxychloroquine and coadministered drugs may be described in the FDA-approved Full Prescribing Information for Plaquenil. 9. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Hydroxychloroquine and reduction of metastasis PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION, Plaquenil Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs Mechanism plaquenilApo hydroxychloroquine 200 mgChloroquine malaria drug Hydroxychloroquine and chloroquine are antimalarial drugs commonly used for the treatment of rheumatic diseases. Multiple mechanisms might explain the efficacy and adverse effects of these drugs. Mechanisms of action of hydroxychloroquine and chloroquine.. Hydroxychloroquine Information for Providers AIDSinfo. Chloroquine & Hydroxychloroquine supporting chemo effectiveness and.. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. Hydroxychloroquine is rapidly absorbed from the gastrointestinal tract, and steady-state concentrations are reached after 4–6 weeks; 45% of hydroxychloroquine binds to plasma proteins that are deposited in tissues such as the liver, spleen, kidney, and lung. I was also diagnosed in August 2013 and also can't take prednisone. I was on plaquenil for 4 - 5 months and my lungs got worse, doc said plaquenil wasn't strong enough. I'm now on 10 mg/wk methotrexate, and sarcoidosis seems to be better.